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AST2818 mesylate

Cat. No. M9400
AST2818 mesylate Structure
Synonym:

Alflutinib mesylate

Size Price Availability Quantity
5mg USD 215  USD215 In stock
10mg USD 320  USD320 In stock
50mg USD 900  USD900 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AST2818 mesylate is a third generation EGFR inhibitor that targets both EGFR activating mutations and T790M thus leading to tumor growth inhibition.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 664.7
Formula C29H35F3N8O5S
CAS Number 2130958-55-1
Purity >99%
Solubility DMSO ≥ 3 mg/mL (Need ultrasonic)
Storage at -20°C
References

[1] Y Shi, et al. J Thorac Oncol. Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Pat-ients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial.

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Keywords: AST2818 mesylate, Alflutinib mesylate supplier, EGFR/HER2, inhibitors

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