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Asiaticoside

Cat. No. M3918
Asiaticoside Structure
Synonym:

Madecassol

Size Price Availability Quantity
10mg USD 50  USD50 In stock
20mg USD 80  USD80 In stock
50mg USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

Asiaticoside is effective in vitro and in vivo in inducing apoptosis and enhancing anti-tumour activity. Asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening. Asiaticosides could inhibit TGF-beta expression, significantly decrease the synthesis and secretion of extracellular matrix, further inhibit the post-stenting intima-media membrane hyperplasia and reduce the endothelial cell damage by effectively up-regulate the expression of Smad7 protein. In vivo studies demonstrated that Asiaticoside could attenuate neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion animals. In addition, Asiaticoside showed anxiolytic effects in acute and chronic stress animals. Pretreatment with Asiaticoside decreased neuronal cell loss in a concentration-dependent manner and restored changes in expression of apoptotic-related proteins Bcl-2 and Bax. In cultured neurons, Asiaticoside significantly inhibited Ca(2+) influx induced by N-methyl-D-aspartate.

Chemical Information
Molecular Weight 959.12
Formula C48H78O19
CAS Number 16830-15-2
Solubility (25°C) DMSO
Ethanol
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qi FY, et al. Neural Regen Res. Neuroprotective effects of Asiaticoside.

[2] Hou SQ, et al. Zhongguo Zhong Yao Za Zhi. [Biochemical regulatory mechanism of asiaticoside in preventing and treating stent restenosis].

[3] Kwon KJ, et al. Mol Med Rep. Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.

[4] Al-Saeedi FJ. BMC Cancer. Study of the cytotoxicity of asiaticoside on rats and tumour cells.

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Keywords: Asiaticoside, Madecassol supplier, TGF-beta/Smad, inhibitors, activators


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