Asiaticoside is effective in vitro and in vivo in inducing apoptosis and enhancing anti-tumour activity. Asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening. Asiaticosides could inhibit TGF-beta expression, significantly decrease the synthesis and secretion of extracellular matrix, further inhibit the post-stenting intima-media membrane hyperplasia and reduce the endothelial cell damage by effectively up-regulate the expression of Smad7 protein. In vivo studies demonstrated that Asiaticoside could attenuate neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion animals. In addition, Asiaticoside showed anxiolytic effects in acute and chronic stress animals. Pretreatment with Asiaticoside decreased neuronal cell loss in a concentration-dependent manner and restored changes in expression of apoptotic-related proteins Bcl-2 and Bax. In cultured neurons, Asiaticoside significantly inhibited Ca(2+) influx induced by N-methyl-D-aspartate.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Neuroprotective effects of Asiaticoside.
Qi FY, et al. Neural Regen Res. 2014 Jul 1;9(13):1275-82. PMID: 25221579.
[Biochemical regulatory mechanism of asiaticoside in preventing and treating stent restenosis].
Hou SQ, et al. Zhongguo Zhong Yao Za Zhi. 2014 Apr;39(8):1479-84. PMID: 25039186.
Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.
Kwon KJ, et al. Mol Med Rep. 2014 Jul;10(1):503-7. PMID: 24756377.
Study of the cytotoxicity of asiaticoside on rats and tumour cells.
Al-Saeedi FJ. BMC Cancer. 2014 Mar 25;14:220. PMID: 24667059.
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