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Ascomycin

Cat. No. M5422
Ascomycin Structure
Synonym:

FR 900520, Immunomycin

Size Price Availability Quantity
10mM*1mL In DMSO USD 65 In stock
5mg USD 50 In stock
10mg USD 60 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 792.01
Formula C43H69NO12
CAS Number 104987-12-4
Purity >98%
Solubility 80 mg/mL in DMSO
Storage at -20°C
References

Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis.
Qi H, et al. J Ind Microbiol Biotechnol. 2014 Sep;41(9):1365-74. PMID: 24965502.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ascomycin, FR 900520, Immunomycin supplier, Anti-infection, inhibitors

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