Free shipping on all orders over $ 500

Asaraldehyde

Cat. No. M3308
Asaraldehyde Structure
Synonym:

Asaronaldehyde

Size Price Availability Quantity
50mg USD 120 In stock
200mg USD 240 In stock
1g USD 480 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Asaraldehyde (Asaronaldehyde) is a selective COX-2 inhibitor. Asaraldehyde (Asaronaldehyde) was found to be the most abundant constituent, but was totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, asaraldehyde (Asaronaldehyde) was produced in both cultured broths. Asaraldehyde (Asaronaldehyde) showed 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/ml. 2,4,5-trimethoxybenzaldehyde showed selectivity towards COX-2 enzyme inhibition at 100 ug/ml. The COX-2/COX-1 ratio for compound 1 was 17.68 at 100 ug/ml compared to solvent control.

Protocol
Cell Experiment
Cell lines 3T3-L1 cells
Preparation method Seeding 3T3-L1 cells in 96-well plates at a concentration of 104 /well. Twenty-four hours later, treating the cells with 100 μg/mL of Asaraldehyde for 24 hours or for the whole 8-day differentiation period. Also, testing fully differentiated adipocytes with 100 μg/mL of Asaraldehyde for 24 hours-72 hours to test the cytotoxicity. Culturing cells with MTT at a final concentration of 0.5 mg/mL for another 4 hours at the end of treatment. The purple MTT formazan is dissolved by DMSO and the absorbance at 570 nm is taken with a spectrophotometer. The absorbance is proportional to the viability of adipocytes
Concentrations 100 μg/mL
Incubation time 24 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 196.2
Formula C10H12O4
CAS Number 4460-86-0
Purity >99%
Solubility DMSO 30 mg/mL
Storage at -20°C
Related COX Products
Vitamin E

Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

Tenoxicam

Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.

Suprofen

Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.

Salicylic acid

Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.

Propyphenazone

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Asaraldehyde, Asaronaldehyde supplier, COX, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.