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Cat. No. M3308
Asaraldehyde Structure


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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Asaraldehyde (Asaronaldehyde) is a selective COX-2 inhibitor. Asaraldehyde (Asaronaldehyde) was found to be the most abundant constituent, but was totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, asaraldehyde (Asaronaldehyde) was produced in both cultured broths. Asaraldehyde (Asaronaldehyde) showed 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/ml. 2,4,5-trimethoxybenzaldehyde showed selectivity towards COX-2 enzyme inhibition at 100 ug/ml. The COX-2/COX-1 ratio for compound 1 was 17.68 at 100 ug/ml compared to solvent control.

Cell Experiment
Cell lines 3T3-L1 cells
Preparation method Seeding 3T3-L1 cells in 96-well plates at a concentration of 104 /well. Twenty-four hours later, treating the cells with 100 μg/mL of Asaraldehyde for 24 hours or for the whole 8-day differentiation period. Also, testing fully differentiated adipocytes with 100 μg/mL of Asaraldehyde for 24 hours-72 hours to test the cytotoxicity. Culturing cells with MTT at a final concentration of 0.5 mg/mL for another 4 hours at the end of treatment. The purple MTT formazan is dissolved by DMSO and the absorbance at 570 nm is taken with a spectrophotometer. The absorbance is proportional to the viability of adipocytes
Concentrations 100 μg/mL
Incubation time 24 hours
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 196.2
Formula C10H12O4
CAS Number 4460-86-0
Purity >98%
Solubility DMSO 30 mg/mL
Storage at -20°C
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Keywords: Asaraldehyde, Asaronaldehyde supplier, COX, inhibitors

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