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AS703026

Cat. No. M1652

AS703026 Structure

Synonym: MSC1936369B,Pimasertib

Size Price Availability Quantity
10mg $120 In stock
50mg $350 In stock
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Quality Control

  • Current batch:
  • Purity >99%
  • COA
  • MSDS

Biological Activity

AS703026 is a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. AS703026 inhibited growth and survival of MM cells and cytokine-induced osteoclast differentiation more potently (9- to 10-fold) than AZD6244. AS703026 further induced apoptosis via caspase 3 and Poly ADP ribose polymerase (PARP) cleavage in MM cells, both in the presence or absence of bone marrow stromal cells (BMSCs).


Chemical Information

Molecular Weight 431.20
Formula C15H15FIN3O3
CAS Number 1236699-92-5
Purity >99%
Solubility DMSO
Storage at -20°C

MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Yoon et al. Cancer Res. 2011 Jan 15;71(2):445-53. PMID: 21118963.

Blockade of the MEK/ERK signaling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
Kihyun et al. Br J Haematol. 2010 May;149(4): 537–549. PMID: 20331454.



Keywords: AS703026, MSC1936369B,Pimasertib, supplier, potent, MEK, kinases, inhibitors, inhibits

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