Free shipping on all orders over $ 500

Arteannuin B

Cat. No. M10360
Arteannuin B Structure
Size Price Availability Quantity
5mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Arteannuin B co-occurs with artemisinin, Arteannuin B shows anti-SARS-CoV-2 potential with an EC50 of 10.28 μM. Artemisinin is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 248.32
Formula C15H20O3
CAS Number 50906-56-4
Purity >98.5%
Solubility DMSO ≥ 30 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

[1] Javeed Ur Rasool, et al. Bioorg Chem. Site selective synthesis and anti-inflammatory evaluation of Spiro-isoxazoline stitched adducts of arteannuin B

[2] Yunjia Hu, et al. Front Cell Infect Microbiol. Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses In Vitro

[3] Yanqing Wang, et al. Pharmaceutics. Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches

[4] Sophia J Lang, et al. Phytomedicine. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients

[5] Chao Zhang, et al. Asian Pac J Trop Med. Effects of arteannuin B, arteannuic acid and scopoletin on pharmacokinetics of artemisinin in mice

Related Anti-infection Products
PF-07321332 (Nirmatrelvir)

PF-07321332 (Nirmatrelvir) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.

Indolicidin

Indolicidin is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils.

Tenuazonic acid

Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate.

ELQ-300

Elq-300 is an antimalarial drug available for biological research and is also an effective oral cytochrome BC1 complex (CYT BC1) reduction (Qi) site inhibitor.

MK-3118

MK-3118 is a novel glucan synthase inhibitor with activity against many echinocandin-resistant strains of Candida due to differential avidity for the target site compared to echinocandins.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Arteannuin B supplier, Anti-infection, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.