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Arformoterol

Cat. No. M13891
Arformoterol Structure
Synonym:

(R,R)-Formoterol

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 344.4
Formula
CAS Number 67346-49-0
Purity >99%
Solubility
Storage at -20°C
References

[1] Young-A Heo. Budesonide/Glycopyrronium/Formoterol: A Review in COPD

[2] Paul M O'Byrne, et al. Inhaled Combined Budesonide-Formoterol as Needed in Mild Asthma

[3] Matthew C Miles, et al. Nebulized arformoterol: what is its place in the management of COPD?

[4] Mario Cazzola, et al. Arformoterol tartrate in the treatment of COPD

[5] Paul King. Role of arformoterol in the management of COPD

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