Aramchol is a cholesterol solubilizer that prevents gallstone formation in inbred mice. Aramchol reduces liver fat content with nonalcoholic fatty liver disease.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 10 mM|
The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease.
Safadi R, et al. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1. PMID: 24815326.
Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice.
Gilat T, et al. Lipids. 2001 Oct;36(10):1135-40. PMID: 11768158.
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