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Aramchol

Cat. No. M9212
Aramchol Structure
Synonym:

Arachidyl amido cholanoic acid

Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 160 In stock
25mg USD 290 In stock
50mg USD 520 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Aramchol is a cholesterol solubilizer that prevents gallstone formation in inbred mice. Aramchol reduces liver fat content with nonalcoholic fatty liver disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 702.10
Formula C44H79NO5
CAS Number 246529-22-6
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease.
Safadi R, et al. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1. PMID: 24815326.

Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice.
Gilat T, et al. Lipids. 2001 Oct;36(10):1135-40. PMID: 11768158.

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