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AP1903 (Rimiducid)

Cat. No. M10066
AP1903 (Rimiducid) Structure
Synonym:

Rimiducid

Size Price Availability Quantity
5mg USD 330  USD330 In stock
10mg USD 478  USD478 In stock
25mg USD 822  USD822 In stock
50mg USD 1353  USD1353 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. In vivo, Rimiducid (0.01, 0.1, 1, 10, and 100 mg/kg; i.v.) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg.

<span style='color:#ff0000;'><strong>*The compound is unstable in solutions, freshly prepared is recommended</strong></span>


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1411.63
Formula C78H98N4O20
CAS Number 195514-63-7
Purity >99%
Solubility DMSO 48 mg/mL
Storage at -20°C
References

[1] D C Thomis, et al. Blood. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

[2] T Clackson, et al. Proc Natl Acad Sci U S A. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

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