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AOA hemihydrochloride

Cat. No. M8879
AOA hemihydrochloride Structure

Carboxymethoxylamine Hemihydrochloride

Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 84  USD84 In stock
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Quality Control
Biological Activity

Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. AOA hemihydrochloride dose-dependently decreases the survival of C6 glioma cells. Aminooxyacetic acid hemihydrochloride treatment produces a significant increase in the percentage of the cells arrested in the stage of G0/G1, as well as a significant decrease in the percentage of the cells at S phase and G2/M phase.

The accumulation of GABA in cerebellum and whole brain is initially very rapid, being significantly increased already 5 min after the injection of Aminooxyacetic acid hemihydrochloride (AOAA). The rapid initial accumulation becomes gradually slower and maximal levels (400 to 600 % of the control levels) are reached 2 to 6 h after Aminooxyacetic acid hemihydrochloride. Still 24 h after Aminooxyacetic acid hemihydrochloride the GABA levels are elevated by about 250%.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 109.3
Formula NH2OCH2COOH · 0.5HCl
CAS Number 2921-14-4
Purity >98%
Solubility DMSO: 40 mg/mL
Storage 4°C, protect from light, dry, sealed

[1] Wang C, et al. Cancer Lett. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis.

[2] Korangath P, et al. Clin Cancer Res. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate.

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Keywords: AOA hemihydrochloride, Carboxymethoxylamine Hemihydrochloride supplier, GABA Receptor, inhibitors

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