Anastrozole can be replaced by letrozole any time during endocrine therapy. The patients taking anastrozole plus letrozole surprisingly seemed to have better OS than patients taking anastrozole alone. Exemestane and anastrozole appear to offer benefit for postmenopausal woman at high risk for invasive breast cancer and are well tolerated. When present first-year data from a direct comparison of anastrozole and letrozole for height augmentation in short pubertal boys. Letrozole was more potent in hormonal manipulation than anastrozole. First-year growth velocities were comparable, but improvement in PAH was greater in the anastrozole group.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Effects of switching from anastrozole to letrozole, due to reimbursement policy, on the outcome of breast cancer therapy.
Aphinives P, et al. Breast Cancer (Dove Med Press). 2014 Aug 27;6:145-50. PMID: 25249759.
Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole.
Ingle JN, et al. Steroids. 2014 Aug 24. PMID: 25163006.
Aromatase Inhibitors in Breast Cancer Prevention.
Olin JL, et al. Ann Pharmacother. 2014 Dec;48(12):1605-1610. PMID: 25159003.
Letrozole vs Anastrozole for Height Augmentation in Short Pubertal Males: First Year Data.
Neely EK, et al. J Clin Endocrinol Metab. 2014 Nov;99(11):4086-93. PMID: 25137428.
|Related Cytochrome P450 (e.g. CYP17) Products|
Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.
Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM.
Naringenin, a common dietary flavonoid abundantly present in fruits and vegetables, is believed to possess strong anti-proliferative properties and the ability to induce apoptosis in hepatoma cell lines.
Voriconazole is an inhibitor of 14α-lanosterol demethylase with IC50 value of 53nM.
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