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Anastrozole

Cat. No. M3708
Anastrozole Structure
Synonym:

Arimidex, ZD1033

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 50 In stock
50mg USD 100 In stock
100mg USD 160 In stock
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Quality Control
Biological Activity

Anastrozole can be replaced by letrozole any time during endocrine therapy. The patients taking anastrozole plus letrozole surprisingly seemed to have better OS than patients taking anastrozole alone. Exemestane and anastrozole appear to offer benefit for postmenopausal woman at high risk for invasive breast cancer and are well tolerated. When present first-year data from a direct comparison of anastrozole and letrozole for height augmentation in short pubertal boys. Letrozole was more potent in hormonal manipulation than anastrozole. First-year growth velocities were comparable, but improvement in PAH was greater in the anastrozole group.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 293.37
Formula C17H19N5
CAS Number 120511-73-1
Purity >99%
Solubility DMSO
Storage at -20°C
References

Effects of switching from anastrozole to letrozole, due to reimbursement policy, on the outcome of breast cancer therapy.
Aphinives P, et al. Breast Cancer (Dove Med Press). 2014 Aug 27;6:145-50. PMID: 25249759.

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole.
Ingle JN, et al. Steroids. 2014 Aug 24. PMID: 25163006.

Aromatase Inhibitors in Breast Cancer Prevention.
Olin JL, et al. Ann Pharmacother. 2014 Dec;48(12):1605-1610. PMID: 25159003.

Letrozole vs Anastrozole for Height Augmentation in Short Pubertal Males: First Year Data.
Neely EK, et al. J Clin Endocrinol Metab. 2014 Nov;99(11):4086-93. PMID: 25137428.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Anastrozole, Arimidex, ZD1033 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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