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Anastrozole

Cat. No. M3708
Anastrozole Structure
Synonym:

Arimidex, ZD1033

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 30  USD30 In stock
50mg USD 84  USD84 In stock
100mg USD 130  USD130 In stock
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Quality Control & Documentation
Biological Activity

Anastrozole can be replaced by letrozole any time during endocrine therapy. The patients taking anastrozole plus letrozole surprisingly seemed to have better OS than patients taking anastrozole alone. Exemestane and anastrozole appear to offer benefit for postmenopausal woman at high risk for invasive breast cancer and are well tolerated. When present first-year data from a direct comparison of anastrozole and letrozole for height augmentation in short pubertal boys. Letrozole was more potent in hormonal manipulation than anastrozole. First-year growth velocities were comparable, but improvement in PAH was greater in the anastrozole group.

Chemical Information
Molecular Weight 293.37
Formula C17H19N5
CAS Number 120511-73-1
Solubility (25°C) DMSO 34 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aphinives P, et al. Breast Cancer (Dove Med Press). Effects of switching from anastrozole to letrozole, due to reimbursement policy, on the outcome of breast cancer therapy.

[2] Ingle JN, et al. Steroids. Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole.

[3] Olin JL, et al. Ann Pharmacother. Aromatase Inhibitors in Breast Cancer Prevention.

[4] Neely EK, et al. J Clin Endocrinol Metab. Letrozole vs Anastrozole for Height Augmentation in Short Pubertal Males: First Year Data.

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Keywords: Anastrozole, Arimidex, ZD1033 supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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