Anastrozole can be replaced by letrozole any time during endocrine therapy. The patients taking anastrozole plus letrozole surprisingly seemed to have better OS than patients taking anastrozole alone. Exemestane and anastrozole appear to offer benefit for postmenopausal woman at high risk for invasive breast cancer and are well tolerated. When present first-year data from a direct comparison of anastrozole and letrozole for height augmentation in short pubertal boys. Letrozole was more potent in hormonal manipulation than anastrozole. First-year growth velocities were comparable, but improvement in PAH was greater in the anastrozole group.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Effects of switching from anastrozole to letrozole, due to reimbursement policy, on the outcome of breast cancer therapy.
Aphinives P, et al. Breast Cancer (Dove Med Press). 2014 Aug 27;6:145-50. PMID: 25249759.
Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole.
Ingle JN, et al. Steroids. 2014 Aug 24. PMID: 25163006.
Aromatase Inhibitors in Breast Cancer Prevention.
Olin JL, et al. Ann Pharmacother. 2014 Dec;48(12):1605-1610. PMID: 25159003.
Letrozole vs Anastrozole for Height Augmentation in Short Pubertal Males: First Year Data.
Neely EK, et al. J Clin Endocrinol Metab. 2014 Nov;99(11):4086-93. PMID: 25137428.
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