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Amlexanox

Cat. No. M5197
Amlexanox Structure
Synonym:

AA673, CHX3673

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Amlexanox is a specific inhibitor of IKKε and TBK1. Amlexanox blocked IKKε activity with a half maximal inhibitory concentration of approximately 1–2 μM. Amlexanox increased phosphorylation of TBK1 on Ser172 in 3T3-L1 adipocytes. Mice treated with amlexanox concurrently with HFD had improved glucose tolerance, with an approximate 30–40% reduction in the area under the curve for glucose. After a 100mg dose of 5% amlexanox topical paste, applied directly to the lesion, the maximum serum concentration of the drug was 120 ng/mL, which was achieved 2.4 hours after application.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 298.29
Formula C16H14N2O4
CAS Number 68302-57-8
Purity >99%
Solubility DMSO
Storage at -20°C
References

Amlexanox for the treatment of recurrent aphthous ulcers.
Bell J. Clin Drug Investig. 2005;25(9):555-66. PMID: 17532700.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Amlexanox, AA673, CHX3673 supplier, IκB/IKK, inhibitors

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