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Alosetron

Cat. No. M5400
Alosetron Structure
Synonym:

GR 68755C, GR 68755

Size Price Availability Quantity
10mg USD 50 In stock
50mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 330.81
Formula C17H18N4O.HCl
CAS Number 122852-69-1
Purity >99%
Solubility 1 mg/mL in water
Storage at -20°C
References

Application of a UPLC-MS/MS method for the analysis of alosetron in human plasma to support a bioequivalence study in healthy males and females.
Chaudhary DV, et al. Biomed Chromatogr. 2015 Oct;29(10):1527-34. PMID: 25761551.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Alosetron, GR 68755C, GR 68755 supplier, 5-HT Receptor, inhibitors

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