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Alda-1

Cat. No. M6423
Alda-1 Structure
Synonym:

Alda1

Size Price Availability Quantity
10mM*1mL In DMSO USD 67 In stock
5mg USD 62 In stock
10mg USD 80 In stock
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Quality Control
Biological Activity

Alda-1 is a potent and selective Aldehyde Dehydrogenase-2 Agonist. Alda-1 increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes.

Alda-1 (8.5 mg/kg, i.p.) with glucose significantly lowers 4-HNE and FJB-positive cells in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration. Alda-1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 324.16
Formula C15H11Cl2NO3
CAS Number 349438-38-6
Purity 99.16%
Solubility DMSO 32.42 mg/mL
Storage at -20°C
References

Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2).
Stachowicz A, et al. Int J Mol Sci. 2017 Feb 17;18(2). PMID: 28218653.

The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression.
Stachowicz A, et al. Brain Behav Immun. 2016 Jan;51:144-53. PMID: 26254233.

Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death.
Ikeda T, et al. PLoS One. 2015 Jun 17;10(6):e0128844. PMID: 26083658.

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Keywords: Alda-1, Alda1 supplier, ALDH, inhibitors

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