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AI-1

Cat. No. M8891
AI-1 Structure
Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 180 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

AI-1 is a negative regulator of Nrf2. AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1). Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 265.69
Formula C13H12ClNO3
CAS Number 75483-04-4
Purity >98%
Solubility DMSO: ≥15 mg/mL
Storage at -20°C
References

Involvement of luxS in Biofilm Formation by Capnocytophaga ochracea.
Hosohama-Saito K, et al. PLoS One. 2016 Jan 22;11(1):e0147114. PMID: 26800339.

Genome-wide RNA sequencing analysis of quorum sensing-controlled regulons in the plant-associated Burkholderia glumae PG1 strain.
Gao R, et al. Appl Environ Microbiol. 2015 Dec;81(23):7993-8007. PMID: 26362987.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AI-1 supplier, inhibitors

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