Free shipping on all orders over $ 500


Cat. No. M8891
AI-1 Structure
Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

AI-1 is a negative regulator of Nrf2. AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1). Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 265.69
Formula C13H12ClNO3
CAS Number 75483-04-4
Purity >98%
Solubility DMSO: ≥15 mg/mL
Storage at -20°C

Involvement of luxS in Biofilm Formation by Capnocytophaga ochracea.
Hosohama-Saito K, et al. PLoS One. 2016 Jan 22;11(1):e0147114. PMID: 26800339.

Genome-wide RNA sequencing analysis of quorum sensing-controlled regulons in the plant-associated Burkholderia glumae PG1 strain.
Gao R, et al. Appl Environ Microbiol. 2015 Dec;81(23):7993-8007. PMID: 26362987.

Related Products

YM-90709 is an interleukin-5 receptor antagonist.


HUHS015 is a potent PCA-1/ALKBH3 inhibitor, which continuously administering HUHS015 significantly suppressed the growth of DU145 cells.

1-methoxy PMS

1-methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.


Erythropoietin (EPO) is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia.


Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.

Abmole Inhibitor Catalog 2017

Keywords: AI-1 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.