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Cat. No. M2312
AG-1478 Structure

Tyrphostin AG-1478

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 40.5  USD45 In stock
10mg USD 58.5  USD65 In stock
25mg USD 117  USD130 In stock
50mg USD 207  USD230 In stock
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Quality Control
Biological Activity

AG-1478 (Tyrphostin AG-1478) is a highly potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with an IC50 of 3 nM. AG-1478 (Tyrphostin AG-1478) reversibly prevents rat brain Kv1.5 potassium channels (IC50 = 9.8 mM) independent of PTK activity. Additionally, AG-1478 (Tyrphostin AG-1478) also suppresses the growth of leiomyoma and myometrium cell cultures with IC50 values of 5.6 and 5.7 mM, respectively. AG-1478 (Tyrphostin AG-1478) blocke the activation of MAP kinase and strongly represses induction of fos gene expression and DNA synthesis. AG-1478 (Tyrphostin AG-1478) blocks G3 enhanced effects on cell apoptosis.

Product Citations
Customer Product Validations & Biological Datas
Source Aging (Albany NY) (2020), Figure 5, AG-1478 (AbMole Bioscience, TX, USA)
Method western blot
Cell Lines cumulus cells
Concentrations 3 μM
Incubation Time 8 h
Results The mRNA of GPR30 was downregulated by EGF stimulation, while AG1478 reversed the inhibition of GPR30 transcription caused by EGF treatment
Source Aging (Albany NY) (2020), Figure 4, AG-1478 (AbMole Bioscience, TX, USA)
Method intraperitoneal injection
Cell Lines mice
Concentrations 1 mg/kg body weight
Incubation Time 1, 3, 5, and 7 day
Results The results showed that hCG significantly activated p-EGFR (Tyr1068), but AG1478 blocked the activation of p-EGFR induced by hCG stimulation
Source Sci Rep (2018). Figure 4. AG-1478
Method western blotting
Cell Lines corneal endothelial cells
Concentrations 1 μM
Incubation Time 7 days
Results The addition of TGF-β1 (with or without AG-1478) also generated the expression of n-cadherin at the cell membrane. The gain of n-cadherin expression following addition of TGF-β1 was confirmed using western blotting
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 315.75
Formula C16H14ClN3O2
CAS Number 153436-53-4
Purity >99%
Solubility DMSO 25 mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog 2017

Keywords: AG-1478, Tyrphostin AG-1478 supplier, EGFR/HER2, inhibitors

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