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Acrovestone

Cat. No. M17306
Acrovestone Structure
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Biological Activity

Acrovestone

Chemical Information
CAS Number 24177-16-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Awat Wisetsai, et al. Nat Prod Res. Acroflavone A, a new prenylated flavone from the fruit of Acronychia pedunculata (L.) Miq

[2] Katsunori Miyake, et al. J Nat Prod. Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis

[3] Chihiro Ito, et al. Nat Prod Commun. Acetophenones Isolated from Acronychia pedunculata and their Anti-proliferative Activities

[4] Eirini Kouloura, et al. J Nat Prod. Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata

[5] T S Wu, et al. J Nat Prod. X-ray crystal structure of acrovestone, a cytotoxic principle from Acronychia pedunculata

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