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Acrivastine

Cat. No. M5286
Acrivastine Structure
Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 240 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In peripheral histamine antagonism as measured by histamine-induced flares and wheals, acrivastine is equipotent to triprolidine and a 4 to 8 mg dose of acrivastine has been shown to be effective in allergic rhinitis. This means that there is considerable separation between the expected therapeutic dose and a dose at which central nervous system impairment might occur.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 348.44
Formula C22H24N2O2
CAS Number 87848-99-5
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

Quantitative determination of acrivastine and pseudoephedrine hydrochloride in pharmaceutical formulation by high performance liquid chromatography and derivative spectrophotometry.
Altuntas TG, et al. J Pharm Biomed Anal. 1998 May;17(1):103-9. PMID: 9608432.

Terfenadine alters action potentials in isolated canine Purkinje fibers more than acrivastine.
Lang DG, et al. J Cardiovasc Pharmacol. 1993 Sep;22(3):438-42. PMID: 7504135.

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