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Acipimox (K-9321) is a nicotinic acid analogue with anti-lipid and anti-lipolysis effects. Acipimox can acutely inhibit lipolysis, inhibit free fat levels throughout the body and improve insulin sensitivity.
Acipimox (0-100 µM; 0-4 hours) enhances leptin release from adipocytes isolated from Sprague-Dawley rats in a time- and dose- dependent manner. Acipimox (10 mM) stimulats leptin release in adipocytes from Streptozotocin (STZ)-treated and Zucker diabetic fat (ZDF) rats. Acipimox (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice.
| Molecular Weight | 154.12 |
| Formula | C6H6N2O3 |
| CAS Number | 51037-30-0 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL Wate 12 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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