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Cat. No. M3301
Acetaminophen Structure

Paracetamol, Tylenol

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 50 In stock
1g USD 60 In stock
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Quality Control
Biological Activity

Acetaminophen is a highly selective inhibitor of COX-2 and 6-keto-PGF1 alpha with IC50 of 302.3 mg/kg and 10 uM, respectively. Administration of high-dose AAP [302.3 mg/kg (IC50 for COX-2)] or PHE [179.2 mg/kg (IC50 for COX-2)] and of non-specific (indomethacin: 20 mg/kg) or specific COX-2 (NS-398: 10 mg/kg) inhibitor impaired the performance in hidden platform (HP) not visible platform (VP) tasks, whereas low-dose (15.1 mg/kg) AAP facilitated performance in HP and VP tasks. Nanomolar concentrations of peroxynitrite increased the activity of isolated PGHS and prostacyclin formation by aortic endothelial cells. This elevated activity was efficiently inhibited by pharmacologically relevant concentrations of acetaminophen (IC50 approximately 10 uM for 6-keto-PGF1alpha) and other free radical scavengers.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 151.16
Formula C8H9NO2
CAS Number 103-90-2
Purity >99%
Solubility DMSO 20 mg/mL
Storage at -20°C
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Keywords: Acetaminophen, Paracetamol, Tylenol supplier, COX, inhibitors

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