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Acerogenin G

Cat. No. M17283
Acerogenin G Structure
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Biological Activity

Acerogenin G (Oil)

Chemical Information
CAS Number 130233-83-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Małgorzata Kubczak, et al. Int J Mol Sci. Molecular Targets of Natural Compounds with Anti-Cancer Properties

[2] Shashanka K Prasad, et al. J Cancer Res Ther. Phytochemical fractions from Annona muricata seeds and fruit pulp inhibited the growth of breast cancer cells through cell cycle arrest at G 0/G 1 phase

[3] Gustavo Alejandro Hernndez-Fuentes, et al. Int J Mol Sci. Cytotoxic Acetogenins from the Roots of Annona purpurea

[4] Douglas Costa Gontijo, et al. Nat Prod Res. Phytochemistry and antiplasmodial activity of Xylopia sericea leaves

[5] Soheil Zorofchian Moghadamtousi, et al. Int J Mol Sci. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

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