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Ac-YVAD-pNA

Cat. No. M8534

All AbMole products are for research use only, cannot be used for human consumption.

Ac-YVAD-pNA Structure

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Biological Activity

Ac-YVAD-pNA is a very selective chromogenic substrate for caspase-1, a key mediator of inflammatory processes formerly known as interleukin (IL)-1-converting enzyme. Ac-YVAD-pNA is used to determine caspase-1 activity. Cleavage of Ac-YVAD-pNA by caspase-1 releases pNA (p-nitroanilide), which can be quantified spectrophotometrically at 405 nm.

Chemical Information
Molecular Weight 628.63
Formula C29H36N6O10
CAS Number 149231-66-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chen Qu, et al. A novel effector caspase (Caspase-3/7-1) involved in the regulation of immune homeostasis in Chinese mitten crab Eriocheir sinensis

[2] Natasha Ann Pereira, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity

[3] A Eckert, et al. Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

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Keywords: Ac-YVAD-pNA supplier, inhibitors, activators

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