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1-Aminobenzotriazole (ABT)

Cat. No. M6389
1-Aminobenzotriazole (ABT) Structure

ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 60  USD60 In stock
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Quality Control
Biological Activity

1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor. 1-Aminobenzotriazole (ABT) inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). 1-Aminobenzotriazole (ABT) reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 134.14
Formula C6H6N4
CAS Number 1614-12-6
Purity 99.63%
Solubility DMSO ≥ 30 mg/mL
Water ≥ 20 mg/mL
Storage at -20°C

[1] Callado, et al. Eur J Pharmacol. α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data.

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Abmole Inhibitor Catalog 2017

Keywords: 1-Aminobenzotriazole (ABT), ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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