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1-Aminobenzotriazole (ABT)

Cat. No. M6389
1-Aminobenzotriazole (ABT) Structure
Synonym:

ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor. 1-Aminobenzotriazole (ABT) inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). 1-Aminobenzotriazole (ABT) reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.

Chemical Information
Molecular Weight 134.14
Formula C6H6N4
CAS Number 1614-12-6
Solubility (25°C) DMSO ≥ 30 mg/mL
Water ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Callado, et al. Eur J Pharmacol. α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data.

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  Catalog
Abmole Inhibitor Catalog




Keywords: 1-Aminobenzotriazole (ABT), ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987 supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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