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Abiraterone Acetate

Cat. No. M3591
Abiraterone Acetate Structure
Synonym:

CB7630

Size Price Availability Quantity
10mg USD 35  USD35 In stock
50mg USD 75  USD75 In stock
100mg USD 100  USD100 In stock
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Quality Control
Biological Activity

Abiraterone Acetate (CB 7630) is a highly active and selective 17α-hydroxylase/17,20 lyase (CYP17A1) inhibitor with an IC50 of 72 nM. Abiraterone Acetate (CB 7630) inhibitor CYP11B1, CYP11B2 and CYP3A4 with IC50 of 1.6, 1.8 and 2.7 μM. Abiraterone Acetate (CB 7630) is used in the study of castration-resistant prostate cancer. Abiraterone Acetate (CB 7630) blocks the formation of testosterone by inhibiting CYP17A1. Abiraterone Acetate (CB 7630) caused significant reductions in the weights of the ventral prostate and seminal vesicles. There was no reduction seen in the weight of these organs with KC. Abiraterone Acetate (CB 7630) reduced plasma testosterone to 0.1 nM or less, despite a three- to four-fold increase in the plasma level of luteinizing hormone (LH).

Protocol
Cell Experiment
Cell lines LNCaP and VCaP cells
Preparation method Seeding LNCaP and VCaP cells in 96-well plates and growing in CSS-supplemented phenol red-free or FBS-supplemented media for 7 days.Treatig cells with Abiraterone at 24 hours and 96 hours after plating and determining cell viability on day 7 by adding CellTiter Glo and measuring luminescence
Concentrations 0 μM -10 μM
Incubation time 24 hours and 96 hours
Animal Experiment
Animal models Male NOD/SCID mice with LAPC4 cells
Formulation 0.1 mL 5% benzyl alcohol and 95% safflower oil solution
Dosages 0.5 mmol/kg/d
Administration Administered via s.c.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 391.55
Formula C26H33NO2
CAS Number 154229-18-2
Purity 99.86%
Solubility Ethanol 20 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Abiraterone Acetate, CB7630 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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