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A 987306 is a potent histamine H4 receptor antagonist (pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively). Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H3, H1 and H2 receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip).
| Molecular Weight | 327.42 |
| Formula | C18H25N5O |
| CAS Number | 1082954-71-9 |
| Solubility (25°C) | DMSO 32.74 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Dorota Lazewska, et al. Azines as histamine H4 receptor antagonists
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