7-amino-4-methylcoumarin (Coumarin 120) is used as a fluorescent probe for many serine proteases. Used for high performance liquid chromatographic labeling.
| Molecular Weight | 175.18 |
| Formula | C10H9NO2 |
| CAS Number | 26093-31-2 |
| Form | Solid |
| Solubility (25°C) | DMSO：10 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Serine/Threonine Protease Products |
|---|
| HC-7366
HC-7366 is an orally bioavailable and efficacious GCN2 kinase activator. |
| Phe-Pro-Ala-pNA
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. |
| Dansyl-Glu-Gly-Arg-Chloromethylketone
Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor, and inhibits serine/threonine proteases. |
| Fluorescent Substrate for Subtillsin
Fluorescent Substrate for Subtillsin can be used to detect the enzyme activity of subtillsin. |
| N-Benzoyl-L-tyrosine p-nitroanilide
N-Benzoyl-L-tyrosine p-nitroanilide is a chymotrypsin substrate. |
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