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6-Thio-2′-Deoxyguanosine

Cat. No. M8490
6-Thio-2′-Deoxyguanosine Structure
Synonym:

6-thio-dG; β-TGdR

Size Price Availability
10mg USD 119 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 283.31
Formula C10H13N5O3S
CAS Number 789-61-7
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage 4°C, protect from light
References

Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.
Mender I, et al. Cancer Discov. 2015 Jan;5(1):82-95. PMID: 25516420.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 6-Thio-2′-Deoxyguanosine, 6-thio-dG; β-TGdR supplier, DNA/RNA Synthesis, inhibitors

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