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6-Aminocaproic acid

Cat. No. M5373
6-Aminocaproic acid Structure
Synonym:

EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid

Size Price Availability Quantity
100mg USD 20  USD20 In stock
500mg USD 30  USD30 In stock
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Quality Control & Documentation
Biological Activity

6-Aminocaproic acid is a derivative and analogue of the amino acid lysine. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis.

Chemical Information
Molecular Weight 131.17
Formula C6H13NO2
CAS Number 60-32-2
Solubility (25°C) Water ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bayram E, et al. Artif Cells Nanomed Biotechnol. A new pyruvate oxidase biosensor based on 3-mercaptopropionic acid/6-aminocaproic acid modified gold electrode.

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Keywords: 6-Aminocaproic acid, EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid supplier, inhibitors, activators


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