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4-Nitroimidazole

Cat. No. M9777
4-Nitroimidazole Structure
Synonym:

4-nitro-1H-imidazole

Size Price Availability Quantity
5g USD 25 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

4-Nitroimidazole is an intermediate during the synthesis of 1-methyl-2,4,5-trinitro imidazole. 4-Nitroimidazole was used in a study to investigate the catalytic efficiency of heterocyclic compounds in the peroxyoxalate chemiluminescence reaction using bis(2,4,6-trichlorophenyl)oxalate as reagent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 113.07
Formula C3H3N3O2
CAS Number 3034-38-6
Purity >98%
Solubility
Storage 18-25°C, dry, sealed
References

Binding of imidazole, 1-methylimidazole and 4-nitroimidazole to yeast cytochrome c peroxidase (CcP) and the distal histidine mutant, CcP(H52L)
James E Erman, et al. Biochim Biophys Acta. 2015 Aug;1854(8):869-81. PMID: 25907133.

Cationic nucleoside lipids derived from universal bases: A rational approach for siRNA transfection
Claire Ceballos, et al. Bioconjug Chem. 2010 Jun 16;21(6):1062-9. PMID: 20481514.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 4-Nitroimidazole, 4-nitro-1H-imidazole supplier, inhibitors

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