4-Nitroimidazole is an intermediate during the synthesis of 1-methyl-2,4,5-trinitro imidazole. 4-Nitroimidazole was used in a study to investigate the catalytic efficiency of heterocyclic compounds in the peroxyoxalate chemiluminescence reaction using bis(2,4,6-trichlorophenyl)oxalate as reagent.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Storage||18-25°C, dry, sealed|
Binding of imidazole, 1-methylimidazole and 4-nitroimidazole to yeast cytochrome c peroxidase (CcP) and the distal histidine mutant, CcP(H52L)
James E Erman, et al. Biochim Biophys Acta. 2015 Aug;1854(8):869-81. PMID: 25907133.
Cationic nucleoside lipids derived from universal bases: A rational approach for siRNA transfection
Claire Ceballos, et al. Bioconjug Chem. 2010 Jun 16;21(6):1062-9. PMID: 20481514.
Thrombin is a trypsin-like allosteric serine protease.
Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and directly inhibits the OGA-stimulated production of H2O2 by soybean cells, even in the absence of other fungal components.
5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), with IC50 of 420 nM and Kd of 170 nM.
Aminopterin is a folic acid derivative used as a rodenticide that has been shown to be teratogenic, and a dihydrofolate reductase inhibitor used to treat rheumatoid arthritis and leukemia.
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