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4-IPP

Cat. No. M6345

All AbMole products are for research use only, cannot be used for human consumption.

4-IPP Structure
Synonym:

4-Iodo-6-phenylpyrimidine

Size Price Availability Quantity
1mg USD 30  USD30 In stock
5mg USD 100  USD100 In stock
10mg USD 160  USD160 In stock
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Biological Activity

4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF) and specific suicide substrate. 4-IPP acts as a suicide substrate to inactivate MIF catalytic and biological functions. 4-IPP inhibits MIF-associated liver enzyme activity in vivo. 4-IPP also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.

Chemical Information
Molecular Weight 282.08
Formula C10H7IN2
CAS Number 41270-96-6
Form Solid
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lin Zheng, et al. Destabilization of macrophage migration inhibitory factor by 4-IPP reduces NF-κB/P-TEFb complex-mediated c-Myb transcription to suppress osteosarcoma tumourigenesis

[2] Shin Heon Lee, et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme

[3] Qiang Xu, et al. Expression of macrophage migration inhibitory factor in Aspergillus fumigatus keratitis

[4] Lin Zheng, et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway

[5] Luca Varinelli, et al. 4-IPP, a selective MIF inhibitor, causes mitotic catastrophe in thyroid carcinomas

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  Catalog
Abmole Inhibitor Catalog




Keywords: 4-IPP, 4-Iodo-6-phenylpyrimidine supplier, Macrophage Migration Inhibitory Factor, inhibitors, activators

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