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4-Biphenylboronic acid

Cat. No. M21544
4-Biphenylboronic acid Structure
Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

4-Biphenylboronic acid is a boric acid compound.

Chemical Information
Molecular Weight 198.03
Formula C12H11BO2
CAS Number 5122-94-1
Solubility (25°C) Insoluble in water
Storage RT, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yusuke Kakei, et al. Plant J. Small-molecule auxin inhibitors that target YUCCA are powerful tools for studying auxin function

[2] Kazuhiko Tsukagoshi, et al. Anal Sci. Enhancing effect of phenylboronic acid compounds and their interactions with the diol groups of saccharides in a capillary electrophoresis-chemiluminescence detection system

[3] L J Kricka, et al. J Biolumin Chemilumin. Super-sensitive enzyme immunoassay for thyroid stimulating hormone using a new synergistic enhanced chemiluminescent endpoint

[4] X Ji, et al. J Biolumin Chemilumin. Effect of enhancers on the pyridopyridazine-peroxide-HRP reaction

[5] O Nozaki, et al. J Biolumin Chemilumin. New enhancers for the chemiluminescent peroxidase catalysed chemiluminescent oxidation of pyrogallol and purpurogallin

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