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3,6'-Disinapoylsucrose

Cat. No. M17451
3,6'-Disinapoylsucrose Structure
Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 210  USD210 In stock
20mg USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

3,6'-Disinapoylsucrose

Chemical Information
CAS Number 139891-98-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yun-Ting Wang, et al. J Asian Nat Prod Res. 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway

[2] Jie Zhang, et al. Biomed Pharmacother. Anxiolytic effects, metabolism and plasma pharmacokinetics of 3, 6' -disinapoylsucrose

[3] Longfei Lin, et al. Biomed Chromatogr. Simultaneous analysis of polygala acid, senegenin and 3,6'-disinapoylsucrose in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study after oral administration

[4] Ying Chen, et al. Planta Med. Intestinal transport of 3,6'-disinapoylsucrose, a major active component of Polygala tenuifolia, using Caco-2 cell monolayer and in situ rat intestinal perfusion models

[5] Ying Chen, et al. Biomed Chromatogr. An LC-MS/MS method for determination of 3,6'-disinapoylsucrose in rat plasma and its application to a pharmacokinetic study

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