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2-Methylserotonin maleate

Cat. No. M8401
2-Methylserotonin maleate Structure
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Biological Activity

2-Methylserotonin is a selective full agonist at the 5-HT3 receptor.

Chemical Information
Molecular Weight 306.31
Formula C11H14N2O · C4H4O4
CAS Number 78263-91-9
Solubility (25°C) Water: 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Osamu Ishizuka, et al. Role of supraspinal serotonin receptors for micturition in normal conscious rats

[2] D Paul, et al. 5-hydroxytryptamine3 (5-HT3) receptors mediate spinal 5-HT antinociception: an antisense approach

[3] S M Martin, et al. Vagal CCK and 5-HT(3) receptors are unlikely to mediate LPS or IL-1beta-induced fever

[4] S Benloucif, et al. Serotonin-facilitated dopamine release in vivo: pharmacological characterization

[5] W Xu, et al. Serotonin receptor subtypes in spinal antinociception in the rat

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