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17α-Estradiol

Cat. No. M10555
17α-Estradiol Structure
Synonym:

Epiestradiol

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

17 alpha-Estradiol is a 5α-reductase inhibitor, and it inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression. Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 272.39
Formula C18H24O2
CAS Number 57-91-0
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Roberta S Santos, et al. Biol Sex Differ. The effects of 17 alpha-estradiol to inhibit inflammation in vitro

[2] Hong-Bing Zhang, et al. Jpn J Ophthalmol. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 17α-Estradiol, Epiestradiol supplier, inhibitors

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