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10-Shogaol

Cat. No. M17318
10-Shogaol Structure
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Biological Activity

10-Shogaol (Oil)

Chemical Information
CAS Number 36752-54-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liangliang He, et al. RSC Adv. Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor

[2] Jeremiah Oshiomame Unuofin, et al. Front Pharmacol. Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

[3] Ali Ghasemzadeh, et al. Molecules. Formation of 6-, 8- and 10-Shogaol in Ginger through Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity

[4] Chung-Yi Chen, et al. Int J Mol Sci. 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer

[5] Yusaku Iwasaki, et al. Nutr Neurosci. A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1

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