10-hydroxy-2-decenoic acid (10-H2DA) is a unique fatty acid found specifically in royal jelly and shows various pharmacological activities.
J Funct Foods. 2022 Aug;Volume 95, 105191.
Royal jelly attenuates LPS-induced immune dysfunction of dendritic cells via Nrf2/HO-1 axis
10-Hydroxy-trans-2-decenoic acid purchased from AbMole
Molecular Weight | 186.25 |
Formula | C10H18O3 |
CAS Number | 14113-05-4 |
Solubility (25°C) | DMSO 20 mg/mL |
Storage | 2-8°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Anna Kurek-Grecka, et al. Bee Products in Dermatology and Skin Care
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