|M9746||CU-CPT-8m||CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8) with Kd of 220 nM and IC50 of 67 nM in assay.|
|M9742||CU-CPT-9a||CU-CPT-9a is a potent TLR8 antagonist with IC50 of 0.5 nM, which that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.|
|M9741||CU-CPT9b||CU-CPT9b is a potent and selective TLR8 inhibitor, with an IC50 of 0.7 nM.|
|M9692||IAXO-102||IAXO-102 is a TLR4 antagonist, which inhibits TLR4 signalling.|
|M9651||TLR4-IN-C34||C34 is a TLR4 inhibitor, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.|
|M9427||CU-CPT17e||CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist, which activates TLR3, TLR8 and TLR9.|
|M9289||E6446 dihydrochloride||E6446 dihydrochloride is a synthetic antagonist of TLR7 and TLR9.|
|M9204||Pam3CSK4||Pam3CSK4 is a Toll-like receptor 1/2 (TLR1/2) agonist.|
|M9063||TLR2-IN-C29||TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling.|
|M7189||Resiquimod||Resiquimod is a toll-like receptor 7 (TLR7) agonist.|
|M5800||Motolimod (VTX-2337)||Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.|
|M5105||MD2-TLR4-IN-1||MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.|
|M4838||TAK-242||TAK-242 (Resatorvid) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling.|
|M2728||GS-9620||GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.|
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