| Cat.No. | Name | Information |
|---|---|---|
| M42066 | Polyinosinic acid | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
| M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
| M9063 | TLR2-IN-C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. |
| M5062 | Polyinosinic:polycytidylic acid | Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M2728 | Vesatolimod (GS-9620) | Vesatolimod (GS-9620) is an effective, selective, oral toll-like receptor 7 (TLR7) agonist with an EC50 value of 291 nM. |
| M58989 | 5-Iodoisoquinoline | 5-Iodoisoquinoline is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. 5-Iodoisoquinoline is selective against other NAD+-processing enzymes, receptors, and transporters. |
| M58317 | Pepinh-TRIF TFA | Pepinh-TRIF TFA blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction. |
| M58146 | TLR4-IN-C34-C2-COOH | TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| M31226 | Chitohexaose hexahydrochloride | Chitohexaose hexahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitohexaose hexahydrochloride binds to the active sites of TLR4 and inhibits LPS induced inflammation. |
| M28034 | Monophosphoryl lipid A | Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine. |
| M21562 | Zymosan A (from Saccharomyces cerevisiae) | Zymosan A can increase the level of cyclin D2, suggesting the role of cyclin D2 in macrophage activation and proliferation. After injection of galactosamine, it aggravated acute liver injury, suggesting that some non-parenchymal cells besides Kupfer's cells were involved in fermentase action. |
| M21418 | CL097 | CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages.CL097 induces NADPH oxidase initiating activity leading to increased fMLF-stimulated ROS production. |
| M20588 | MD2-IN-1 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM. |
| M19443 | Robinin | Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway. |
| M16160 | Stepharine | Stepharine is an natural alkaloid which directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects. |
| M14130 | Pam3CSK4 TFA | Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2. |
| M14128 | Imiquimod hydrochloride | Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. |
| M11434 | Enpatoran | Enpatoran (M5049) is a potentially "first-in-class" orally active Toll-like receptor (TLR) 7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells. |
| M11423 | RS 09 | RS09 is a LPS peptide mimicry, which is a new class of TLR4 agonist adjuvant. RS09 can increase antibody production in a vaccine environment. |
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