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TLR Toll-like Receptor

Inhibitors

Cat.No.  Name Information
M2227 Imiquimod Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a selective toll like receptor 7 (TLR7) agonist. with potent indirect antiviral activity.
M4838 TAK-242 (Resatorvid) Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases.
M21418 CL097 CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages.CL097 induces NADPH oxidase initiating activity leading to increased fMLF-stimulated ROS production.
M20017 CL-104773 CL-104773 is a TLR2 antagonist
M14130 Pam3CSK4 TFA Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.
M14129 MMG-11 quarterhydrate MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity.
M14128 Imiquimod hydrochloride Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist.
M14127 FSL-1 TFA FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
M11461 Enpatoran hydrochloride Enpatoran (M5049) Hydrochloride is a potent and orally active inhibitor of TLR7/8, with IC50s of 11.1 nM and 24.1 nM in HEK293 cells.
M11434 Enpatoran Enpatoran (M5049) is a potentially "first-in-class" orally active Toll-like receptor (TLR) 7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells.
M11423 RS 09 RS09 is a LPS peptide mimicry, which is a new class of TLR4 agonist adjuvant. RS09 can increase antibody production in a vaccine environment.
M11411 1V209 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist with antitumor effects. 1V209 can be conjugated with various polysaccharides to improve their water solubility, enhance efficacy and maintain low toxicity.
M11407 FSL-1 TFA Fsl-1 TFA is a bacteria-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. Fsl-1 TFA induces mMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways.
M11308 E6446 E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro.
M11026 CU-T12-9 Cu-t12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM. Cu-t12-9 activates both the innate and adaptive immune systems.
M10918 TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist 1 dihydrochloride is a dual agonist of toll-like receptor TLR7/TLR8.
M10846 LHC-165 LHC-165 is an agonist of Toll-like receptor 7 (TLR7). There is potential to study solid tumors.
M10813 DSR-6434 DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist for both humans and mice with TLR7 EC50 7.2 nM and 4.6 nM, respectively. DSR-6434 has a strong antitumor effect.
M10810 CU-115 CU-115 is a powerful TLR8 antagonist (IC50=1.04 µM), AND SHOWS A HIGHER SELECTIVITY FOR TLR8 THAN TLR7 (IC50=>50 µM)。 CU-115 reduces the production of TNF-α and IL-1β in THP-1 cells activated by R-848.
M10790 AZD8848 AZD8848 is a selective TLR7 precursor drug agonist for the study of asthma and allergic rhinitis.
M10703 PF-4878691 PF-4878691 (3M-852A) is a highly potent, orally active, selective Toll-like receptor 7 (TLR7) agonist that separates its antiviral activity from its inflammatory activity.
M10331 CRX-527 CRX-527 is a highly specific and potent TLR4 agonist, which displays significantly less toxicity when compared to LPS.



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