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  Catalog
Abmole Inhibitor Catalog 2017

TLR Toll-like Receptor

Inhibitors

Cat.No.  Name Information
M9746 CU-CPT-8m CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8) with Kd of 220 nM and IC50 of 67 nM in assay.
M9742 CU-CPT-9a CU-CPT-9a is a potent TLR8 antagonist with IC50 of 0.5 nM, which that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.
M9741 CU-CPT9b CU-CPT9b is a potent and selective TLR8 inhibitor, with an IC50 of 0.7 nM.
M9692 IAXO-102 IAXO-102 is a TLR4 antagonist, which inhibits TLR4 signalling.
M9651 TLR4-IN-C34 C34 is a TLR4 inhibitor, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
M9427 CU-CPT17e CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist, which activates TLR3, TLR8 and TLR9.
M9289 E6446 dihydrochloride E6446 dihydrochloride is a synthetic antagonist of TLR7 and TLR9.
M9204 Pam3CSK4 Pam3CSK4 is a Toll-like receptor 1/2 (TLR1/2) agonist.
M9063 TLR2-IN-C29 TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling.
M7189 Resiquimod Resiquimod is a toll-like receptor 7 (TLR7) agonist.
M5800 Motolimod (VTX-2337) Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.
M5105 MD2-TLR4-IN-1 MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.
M4838 TAK-242 TAK-242 (Resatorvid) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling.
M2728 GS-9620 GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.


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