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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9746 | CU-CPT-8m | CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8) with Kd of 220 nM and IC50 of 67 nM in assay. |
| M9742 | CU-CPT-9a | CU-CPT-9a is a potent TLR8 antagonist with IC50 of 0.5 nM, which that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. |
| M9741 | CU-CPT9b | CU-CPT9b is a potent and selective TLR8 inhibitor, with an IC50 of 0.7 nM. |
| M9692 | IAXO-102 | IAXO-102 is a TLR4 antagonist, which inhibits TLR4 signalling. |
| M9651 | TLR4-IN-C34 | C34 is a TLR4 inhibitor, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| M9427 | CU-CPT17e | CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist, which activates TLR3, TLR8 and TLR9. |
| M9289 | E6446 dihydrochloride | E6446 dihydrochloride is a synthetic antagonist of TLR7 and TLR9. |
| M9204 | Pam3CSK4 | Pam3CSK4 is a Toll-like receptor 1/2 (TLR1/2) agonist. |
| M9063 | TLR2-IN-C29 | TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. |
| M7189 | Resiquimod | Resiquimod is a toll-like receptor 7 (TLR7) agonist. |
| M5800 | Motolimod (VTX-2337) | Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2. |
| M5105 | MD2-TLR4-IN-1 | MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. |
| M4838 | TAK-242 | TAK-242 (Resatorvid) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling. |
| M2728 | GS-9620 | GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7. |
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