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TLR Toll-like Receptor

Cat.No.  Name Information
M4838 TAK-242 (Resatorvid) Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases.
M11408 Hydroxychloroquine Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection.
M9063 TLR2-IN-C29 C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively.
M42066 Polyinosinic acid Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist.
M5062 Polyinosinic acid: polycytidylic acid (poly I:C) Polyinosinic acid: polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses.
M5062 Polyinosinic acid: polycytidylic acid (poly I:C) Polyinosinic acid: polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses.
M4539 Polygalasaponin-F Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway.
M4519 Procyanidin-B1 Procyanidin B1 is a polyphenolic flavonoid that exists in common fruits and can bind to TLR4/MD-2 complex, showing anti-inflammatory activity.
M4341 Schaftoside Schaftoside is a flavonoid found in a variety of Chinese herbs such as Eleusine indica. Schaftoside inhibited TLR4 and Myd88 expression. Schaftoside also reduced Drp1 expression and phosphorylation, and reduced mitochondrial division.
M4288 Atractylenolide I Atractylenolide I is a sesquiterpene obtained from the roots of Atractylenolide. Atractylenolide I has neuroprotective, anti-allergic, anti-inflammatory and anticancer activities. Atractylenolide I is an antagonist of TLR4 and can also reduce the phosphorylation of JAK2 and STAT3 in A375 cells.
M2728 Vesatolimod (GS-9620) Vesatolimod (GS-9620) is an effective, selective, oral toll-like receptor 7 (TLR7) agonist with an EC50 value of 291 nM.
M54728 Kdo2-Lipid A ammonium Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxic activity equivalent to LPS.Kdo2-Lipid A ammonium is highly selective for TLR4 and stimulates the release of TNF and PGE2.
M54417 PSMα3 PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies.
M52830 Pam2CSK4 Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist.
M49647 MAPK-IN-1 MAPK-IN-1 is a MAPK signaling pathway inhibitor.
M45111 Cobitolimod Cobitolimod is a first-of-its-kind (first-in-class), synthetic oligodeoxynucleotide (ODN) containing unmethylated CpG motifs that activates TLR9 in specific cells, including intestinal T and B lymphocytes as well as antigen-presenting cells (APCs), and can be used in studies related to inflammatory bowel disease (IBD).
M43824 Agatolimod Agatolimod is a class B ODN (Oligodeoxynucleotide) and also a TLR9 agonist that stimulates HD11 cells to produce NO2 and IL-6, which can be used in breast cancer related studies. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'.
M43823 Lefitolimod Lefitolimod is a DNA-based TLR9 agonist and immunosurveillance reactivator that induces HIV-specific immune responses for cancer and HIV-1 research.
M43822 SD-101 SD-101 is a TLR9 agonist that can be used in tumor-related studies.
M43821 Vidutolimod Vidutolimod is a CpG-a oligonucleotide packaged within virus-like particles formed by the phage shell protein Qβ and an agonist of TLR9, which activates plasmacytoid dendritic cells (pDCs) and triggers the release of IFNα, with antitumor activity.
M42073 TLR7 agonist 9 TLR7 agonist 9 is an aonist of TLR7.
M42072 TLR8 agonist 6 TLR8 agonist 6 is a TLR8 agonist, with an EC50 of 0.052 μM.
M42071 TLR7/8/9 antagonist 2 TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist.
M42070 Guretolimod hydrochloride Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist.
M42069 RDR 02308 RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase.




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