Cat.No. | Name | Information |
---|---|---|
M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
M9063 | TLR2-IN-C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. |
M42066 | Polyinosinic acid | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
M5062 | Polyinosinic acid: polycytidylic acid (poly I:C) | Polyinosinic acid: polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
M5062 | Polyinosinic acid: polycytidylic acid (poly I:C) | Polyinosinic acid: polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
M4539 | Polygalasaponin-F | Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway. |
M4519 | Procyanidin-B1 | Procyanidin B1 is a polyphenolic flavonoid that exists in common fruits and can bind to TLR4/MD-2 complex, showing anti-inflammatory activity. |
M4341 | Schaftoside | Schaftoside is a flavonoid found in a variety of Chinese herbs such as Eleusine indica. Schaftoside inhibited TLR4 and Myd88 expression. Schaftoside also reduced Drp1 expression and phosphorylation, and reduced mitochondrial division. |
M4288 | Atractylenolide I | Atractylenolide I is a sesquiterpene obtained from the roots of Atractylenolide. Atractylenolide I has neuroprotective, anti-allergic, anti-inflammatory and anticancer activities. Atractylenolide I is an antagonist of TLR4 and can also reduce the phosphorylation of JAK2 and STAT3 in A375 cells. |
M2728 | Vesatolimod (GS-9620) | Vesatolimod (GS-9620) is an effective, selective, oral toll-like receptor 7 (TLR7) agonist with an EC50 value of 291 nM. |
M54728 | Kdo2-Lipid A ammonium | Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxic activity equivalent to LPS.Kdo2-Lipid A ammonium is highly selective for TLR4 and stimulates the release of TNF and PGE2. |
M54417 | PSMα3 | PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. |
M52830 | Pam2CSK4 | Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. |
M49647 | MAPK-IN-1 | MAPK-IN-1 is a MAPK signaling pathway inhibitor. |
M45111 | Cobitolimod | Cobitolimod is a first-of-its-kind (first-in-class), synthetic oligodeoxynucleotide (ODN) containing unmethylated CpG motifs that activates TLR9 in specific cells, including intestinal T and B lymphocytes as well as antigen-presenting cells (APCs), and can be used in studies related to inflammatory bowel disease (IBD). |
M43824 | Agatolimod | Agatolimod is a class B ODN (Oligodeoxynucleotide) and also a TLR9 agonist that stimulates HD11 cells to produce NO2 and IL-6, which can be used in breast cancer related studies. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'. |
M43823 | Lefitolimod | Lefitolimod is a DNA-based TLR9 agonist and immunosurveillance reactivator that induces HIV-specific immune responses for cancer and HIV-1 research. |
M43822 | SD-101 | SD-101 is a TLR9 agonist that can be used in tumor-related studies. |
M43821 | Vidutolimod | Vidutolimod is a CpG-a oligonucleotide packaged within virus-like particles formed by the phage shell protein Qβ and an agonist of TLR9, which activates plasmacytoid dendritic cells (pDCs) and triggers the release of IFNα, with antitumor activity. |
M42073 | TLR7 agonist 9 | TLR7 agonist 9 is an aonist of TLR7. |
M42072 | TLR8 agonist 6 | TLR8 agonist 6 is a TLR8 agonist, with an EC50 of 0.052 μM. |
M42071 | TLR7/8/9 antagonist 2 | TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. |
M42070 | Guretolimod hydrochloride | Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist. |
M42069 | RDR 02308 | RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase. |
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