| Cat.No. | Name | Information |
|---|---|---|
| M14000 | Fingolimod | Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. |
| M9383 | Opaganib | Opaganib (ABC294640) is a selective and competitive SK2 inhibitor with a Ki of 9.8 μM. |
| M2797 | KRP-203 hydrochloride | Mocravimod (KRP-203) hydrochloride is a potent, orally active sphingosine receptor S1P1 and S1P4 agonist with EC50s of 1 nM and 10 nM, respectively, and may be used in studies related to ulcerative colitis (UC). |
| M2546 | CYM-5442 | CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 can easily penetrate the central nervous system (CNS). |
| M2428 | BAF312 | BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. |
| M1712 | FTY720 hydrochloride | Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. |
| M29512 | S1PR1 modulator 1 | S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4. |
| M28696 | Ozanimod hydrochloride | Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS) . |
| M28557 | Icanbelimod | Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P1 receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). |
| M28339 | Vibozilimod | Vibozilimod (SCD-044, example 33) is a S1P1 receptor agonist. |
| M24539 | Sonepcizumab | Sonepcizumab (LT 1009) is a fully humanized anti-S1P monoclonal antibody. Sonepcizumab has the potential for the research of metastatic renal cell carcinoma (mRCC). |
| M13998 | ASP-4058 | ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. |
| M10226 | Etrasimod (APD334) | Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor, with IC50 of 1.88 nM in CHO cells. |
| M8784 | NIBR-0213 | NIBR-0213 is an orally active, potent and S1P1-selective sphingosine 1-phosphate (S1P) receptor antagonist. |
| M8431 | CYM50358 | CYM50358 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). |
| M7570 | Amiselimod hydrochloride | Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. |
| M7560 | Cenerimod | Cenerimod (ACT-334441) is a potentially first-in-class (first-in-class), potent, highly selective, orally active sphingosine 1-phosphate 1 (S1P1) receptor agonist with an EC50 value of 2.7 nM for use in studies related to systemic lupus erythematosus (SLE). |
| M7438 | TY 52156 | TY 52156 is a s1P3 receptor antagonist. |
| M7319 | Sphingosine-1-phosphate | Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. |
| M6643 | CYM 5520 | CYM 5520 is a selective S1P2 allosteric agonist. |
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