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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9455 | PF-543 Citrate | PF-543 Citrate is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. |
| M9383 | Opaganib (ABC294640) | Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. |
| M8784 | NIBR-0213 | NIBR-0213 is an orally active, potent and S1P1-selective sphingosine 1-phosphate (S1P) receptor antagonist that blocks S1P1-selective ligand AUY954-induced Ca2+ mobilization (IC50 = 2. |
| M8646 | A-971432 | A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50 >10 μM). |
| M8611 | Ex26 | Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0. |
| M8431 | CYM50358 | CYM50358 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). |
| M7570 | Amiselimod hydrochloride | Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. |
| M7560 | Cenerimod | Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. |
| M7465 | VPC 23019 | VPC 23019 is a s1P1 and S1P3 antagonist. |
| M7438 | TY 52156 | TY 52156 is a s1P3 receptor antagonist. |
| M7319 | Sphingosine-1-phosphate | Sphingosine-1-phosphate is a endogenous agonist at S1P1-5. |
| M7214 | RP 001 hydrochloride | RP 001 hydrochloride is a potent S1P1 agonist. |
| M6643 | CYM 5520 | CYM 5520 is a selective S1P2 allosteric agonist. |
| M6642 | CYM 50260 | CYM 50260 is a potent and selective S1P4 agonist. |
| M5886 | Ponesimod | Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. |
| M5244 | Ozanimod | Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. |
| M3129 | W146 | W146 is a potent S1P1 selective antagonist with Ki of 18 nM. |
| M3012 | SKI II | SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. |
| M2797 | KRP-203 | KRP-203 is a S1P1 and S1P4 receptors agonist with EC50 of 1 nM and 10 nM, respectively. |
| M2787 | JTE 013 | JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
| M2546 | CYM-5442 hydrochloride | CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. |
| M2428 | BAF312 | BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. |
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