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  Catalog
Abmole Inhibitor Catalog 2017

S1P Receptor S1P Receptor

Inhibitors

Cat.No.  Name Information
M8784 NIBR-0213 NIBR-0213 is an orally active, potent and S1P1-selective sphingosine 1-phosphate (S1P) receptor antagonist that blocks S1P1-selective ligand AUY954-induced Ca2+ mobilization (IC50 = 2.
M8646 A-971432 A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50 >10 μM).
M8611 Ex26 Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.
M8431 CYM50358 CYM50358 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4).
M7570 Amiselimod hydrochloride Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.
M7560 Cenerimod Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM.
M7465 VPC 23019 VPC 23019 is a s1P1 and S1P3 antagonist.
M7438 TY 52156 TY 52156 is a s1P3 receptor antagonist.
M7319 Sphingosine-1-phosphate Sphingosine-1-phosphate is a endogenous agonist at S1P1-5.
M7214 RP 001 hydrochloride RP 001 hydrochloride is a potent S1P1 agonist.
M6643 CYM 5520 CYM 5520 is a selective S1P2 allosteric agonist.
M6642 CYM 50260 CYM 50260 is a potent and selective S1P4 agonist.
M5886 Ponesimod Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.
M5244 Ozanimod Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator.
M3129 W146 W146 is a potent S1P1 selective antagonist with Ki of 18 nM.
M3012 SKI II SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2.
M2797 KRP-203 KRP-203 is a S1P1 and S1P4 receptors agonist with EC50 of 1 nM and 10 nM, respectively.
M2787 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.
M2546 CYM-5442 hydrochloride CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM.
M2428 BAF312 BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.


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