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Fingolimod

Cat. No. M14000
Fingolimod Structure
Synonym:

FTY720 free base

Size Price Availability Quantity
100mg USD 60  USD60 In stock
200mg USD 90  USD90 In stock
500mg USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.

Product Citations
Chemical Information
Molecular Weight 307.47
Formula C19H33NO2
CAS Number 162359-55-9
Form Solid
Solubility (25°C) Ethanol 7.69 mg/mL
DMSO 2 mg/mL (ultrasonic and heat to 60°C)
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mauro Zaffaroni. Fingolimod in pediatric-onset multiple sclerosis

[2] Elyse Swallow, et al. Comparative safety and efficacy of ozanimod versus fingolimod for relapsing multiple sclerosis

[3] Jerold Chun, et al. Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders

[4] Andrea Huwiler, et al. The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives

[5] P Mandal, et al. Fingolimod: therapeutic mechanisms and ocular adverse effects

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Keywords: Fingolimod, FTY720 free base supplier, S1P Receptor, inhibitors, activators


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