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Parasite Antiparasitics

Cat.No.  Name Information
M38780 Methylenetanshinquinone Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection.
M38779 9-Hydroxycalabaxanthone 9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 µM).
M38778 Betulinic acid methyl ester Betulinic acid methyl ester, a betulinic acid derivative, possesses antiprotozoal activity.
M38777 3′,4′,5′,5,6,7-Hexamethoxyflavone 3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC50 of 21.3 μM (8.58 g/mL).
M38776 1-(26-Hydroxyhexacosanoyl)-glycerol 1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC50 value of 9.48 µM for Plasmodium falciparum.
M31190 Nitidanin Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection.
M30870 Piperaquine tetraphosphate  Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria.
M30864 Diethylcarbamazine  Diethylcarbamazine is a microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis study.
M30834 MMV665916  MMV665916, a quinazolinedione derivative, is an antimalarial agent. MMV665916 displays antiplasmodial activity against P. falciparum FcB1 strain with EC50 value of 0.4 µM and presents the high selectivity index (SI>250).
M30610 Hexythiazox Hexythiazox is a selective acaricide with ovicidal, larvicidal and nymphicidal activities. Hexythiazox is widely used for chemical control of mites on cotton, fruits and vegetables. Hexythiazox is harmless to mammals and has no effect on beneficial insects and predators of mites.
M30538 Laetanine  Laetanine, a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity.
M30496 Toltrazuril (sulfone) Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril, with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry.
M30417 Alstonine  Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.
M30226 Cycloguanil Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
M30077 Carnidazole Carnidazole is an antiprotozoal agent of the nitroimidazole class. Carnidazole is used for the research of Trichomonas infection.
M30057 Piperaquine  Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin.
M29967 Endochin  Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis.
M29939 ICA ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.
M29743 Amoscanate Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma.
M29727 WM382  WM382 is an orally active and potent dual plasmepsin IX/X (PMIX/X) inhibitor with IC50 values of 1.4 nM and 0.03 nM, respectively. WM382 has robust in vivo efficacy at multiple stages of the malaria parasite life cycle and an excellent resistance profile.




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