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Abmole Inhibitor Catalog 2017

P2 Receptor Purinergic2 receptors


Cat.No.  Name Information
M10442 Minodronic acid Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors, Minodronic acid (YM-529) is also a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells.
M9819 BAY-1797 BAY-1797 is a potent and selective, orally active P2X4 antagonist, with IC50 value of 211 nM for human P2X4.
M9740 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50 values of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively.
M9182 Gefapixant Gefapixant, also known as AF-219 or MK-7264, is a P2X3 receptor antagonist.
M6374 A 804598 A 804598 is a potent and selective P2X7 antagonist.
M6347 5-BDBD 5-BDBD is a potent P2X4 receptor antagonist.
M5986 Suramin sodium salt Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM).
M5023 Clopidogrel hydrogen sulfate S-(+)-Clopidogrel Hydrogen Sulfate is the S enantiomer of clopidogrel and a P2Y12 receptor inhibitor.
M3280 Clopidogrel Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
M3233 GW791343 trihydrochloride GW791343 trihydrochloride is ahydrochloride salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
M3185 Ticlopidine hydrochloride Ticlopidine hydrochloride is a selective P2Y12 receptor antagonist.
M3069 Ticagrelor Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM respectively.
M2954 PPADS Tetrasodium Salt PPADS tetrasodium salt is a non-selective P2 purinergic antagonist blocking recombinant P2X1, P2X2, P2X3, P2X5 with IC50 of 1-2.6 μM, native P2Y2-like with IC50 of ~ 0.9 mM, and recombinant P2Y4 receptors with IC50 of ~ 15 mM
M2869 MRS 2578 MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.
M2234 Prasugrel Prasugrel is a platelet inhibitor irreversibly binding to P2Y12 receptors.
M1909 GW 791343 dihydrochloride GW 791343 dihydrochloride is a non-competitive inhibitor of human P2X(7) receptor.
M1895 Prasugrel hydrochloride Prasugrel hydrochloride is a novel inhibitor of platelet activation and aggregation.

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