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Suramin sodium salt

Cat. No. M5986
Suramin sodium salt Structure
Size Price Availability Quantity
50mg USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1429.17
Formula C51H34N6Na6O23S6
CAS Number 129-46-4
Purity >99%
Solubility 100 mg/mL in water
Storage at -20°C
References

Suramin Inhibits Chikungunya Virus Entry and Transmission.
Ho YJ, et al. PLoS One. 2015 Jul 24;10(7):e0133511. PMID: 26208101.

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Keywords: Suramin sodium salt supplier, P2 Receptor, inhibitors

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