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Suramin sodium salt

Cat. No. M5986
Suramin sodium salt Structure
Synonym:

Suramin hexasodium salt; BAY-205; NF-060

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 135  USD135 In stock
25mg USD 290  USD290 In stock
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Quality Control & Documentation
Biological Activity

Suramin Sodium Salt (Suramin hexasodium salt) is a reversible inhibitor of competitive protein tyrosine phosphatases (PTPases). Suramin Sodium Salt is an effective sirtuins inhibitor: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), SirT5 (IC50=22 μM). Suramin Sodium Salt is a potent INHIBITOR of SARS-COV-2 RNA-dependent RNA polymerase (RdRp). Suramin sodium salt was effective in inhibiting IP5K and was regarded as an antiparasitic, antitumor and antiangiogenic agent from medine to Medine.

Product Citations
Chemical Information
Molecular Weight 1429.17
Formula C51H34N6Na6O23S6
CAS Number 129-46-4
Solubility (25°C) 100 mg/mL in water
Storage 4°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ho YJ, et al. PLoS One. Suramin Inhibits Chikungunya Virus Entry and Transmission.

[2] Mohamed Izikki, et al. PLoS One. The Beneficial Effect of Suramin on Monocrotaline-Induced Pulmonary Hypertension in Rats

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Keywords: Suramin sodium salt, Suramin hexasodium salt; BAY-205; NF-060 supplier, P2 Receptor, inhibitors, activators


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