Suramin Sodium Salt (Suramin hexasodium salt) is a reversible inhibitor of competitive protein tyrosine phosphatases (PTPases). Suramin Sodium Salt is an effective sirtuins inhibitor: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), SirT5 (IC50=22 μM). Suramin Sodium Salt is a potent INHIBITOR of SARS-COV-2 RNA-dependent RNA polymerase (RdRp). Suramin sodium salt was effective in inhibiting IP5K and was regarded as an antiparasitic, antitumor and antiangiogenic agent from medine to Medine.
Am J Pathol. 2020 Apr 11;S0002-9440(20)30191-7.
Silent Mating-Type Information Regulation 2 Homolog 1 Attenuates the Neurotoxicity Associated With Alzheimer Disease via a Mechanism Which May Involve Regulation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-α
Suramin sodium salt purchased from AbMole
Molecular Weight | 1429.17 |
Formula | C51H34N6Na6O23S6 |
CAS Number | 129-46-4 |
Solubility (25°C) | 100 mg/mL in water |
Storage | 4°C, dry, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Ho YJ, et al. PLoS One. Suramin Inhibits Chikungunya Virus Entry and Transmission.
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