Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M8692 | ML385 | ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1. |
| M10081 | Omaveloxolone | Omaveloxolone (RTA 408) is a first-in-class antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO). Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway. |
| M8710 | Brusatol | Brusatol (NSC 172924) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2. |
| M8404 | Danshensu | Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia. |
| M6976 | ML 334 | ML334 (LH601A) is a inhibitor of Keap1- Nrf2 interaction. |
| M4588 | Astilbin | Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation. |
| M4072 | Ginsenoside-Rh3 | Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 induces Nrf2 activation in human retinal cells. |
| M52372 | [D-Asp3]-Microcystin-LR | Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. |
| M52371 | Keap1-Nrf2 probe | Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 probe. |
| M50196 | BAY-3605349 | BAY-3605349 is an orally active Kelch-like ECH-associated protein 1 (KEAP1) activator as well as Nrf2 inhibitor for tumor-related studies. |
| M49741 | Nrf2/HO-1 activator 1 | Nrf2/HO-1 activator 1 is a potent Nrf2/HO-1 activator, neuroprotective agent. |
| M49646 | Nrf2/HO-1 activator 2 | Nrf2/HO-1 activator 2 , difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. |
| M42737 | Nrf2-IN-3 | Nrf2-IN-3 is a Nrf2 inhibitor. |
| M42736 | Nrf2 activator-3 | Nrf2 activator-3 is a potent Nrf2 activator. |
| M42735 | Keap1-Nrf2-IN-16 | Keap1-Nrf2-IN-16 is a biological active peptide. |
| M42734 | Nrf2 activator-8 | Nrf2 activator-8 is a Nrf2 activator (EC50=37.9 nM). |
| M42733 | S217879 | S217879 is a highly potent and selective NRF2 activator. |
| M42732 | Rosolic acid | Rosolic Acid is an activator of Nrf2, as well as its downstream targets. |
| M42731 | I-152 | I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). |
| M42730 | Nrf2 activator-7 | Nrf2 activator-7 is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway. |
| M42729 | Keap1-Nrf2-IN-15 | Keap1-Nrf2-IN-15 is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC50s of 77 nM and 2.5 nM in FP assay and TR-FRET assay, respectively. |
| M42728 | Microcystin-LY | Microcystin-LY acts as an activator of the Nrf2 pathway to induce oxidative stress response, and the induction effect is most obvious at 3μM.. |
| M40965 | BMX-010 chloride | BMX-010 chloride is a ROS scavenger and NRF2 agonist with potent antiradical activity for studies related to atopic dermatitis and psoriasis. |
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