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Brusatol

Cat. No. M8710
Brusatol Structure
Synonym:

(+)-Brusatol

Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 170  USD170 In stock
20mg USD 270  USD270 In stock
50mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2.

Product Citations
Chemical Information
Molecular Weight 520.53
Formula C26H32O11
CAS Number 14907-98-3
Solubility (25°C) DMSO: 12 mg/mL (warmed)
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tao Wang, et al. Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway

[2] Jianhui Xie, et al. Apoptotic activities of brusatol in human non-small cell lung cancer cells: Involvement of ROS-mediated mitochondrial-dependent pathway and inhibition of Nrf2-mediated antioxidant response

[3] Songbin Guo, et al. Anticancer effects of brusatol in nasopharyngeal carcinoma through suppression of the Akt/mTOR signaling pathway

[4] Sabrina J Cai, et al. Brusatol, an NRF2 inhibitor for future cancer therapeutic

[5] Shu-Zhi Hu, et al. Brusatol

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Keywords: Brusatol, (+)-Brusatol supplier, Keap1-Nrf2, inhibitors, activators


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