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NLR NOD-like Receptor

Inhibitors

Cat.No.  Name Information
M8083 MCC950 sodium salt (CP-456773) MCC950 (CP-456773) sodium salt was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome.
M6164 MCC950 MCC950 (CP-456773) is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
M20827 BMS-986299 BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
M14102 Cardamonin Cardamonin (Cardamomin) acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
M13338 Trimethylamine N-oxide Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
M10838 JC124 JC124 IS A SPECIFIC INHIBITOR OF THE NLRP3 INFLAMMASOME. JC124 HAS ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS.
M10629 Troxerutin Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.
M10136 GSK717 GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor.
M9516 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor able to decrease interleukin-1β release from macrophages. *The compound is unstable in solutions, freshly prepared is recommended
M9376 Dapansutrile (OLT1177) Dapansutrile (OLT1177) is a first-in-class potent, selective and orally active inhibitor of NLRP3 inflammasome.
M9263 CY-09 CY-09 is a selective and direct NLRP3 inhibitor.
M8083 MCC950 sodium salt (CP-456773) MCC950 (CP-456773) sodium salt was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome.
M7547 NOD-IN-1 NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
M6164 MCC950 MCC950 (CP-456773) is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
M5301 (E)-Cardamonin (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
M4578 Oridonin Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
M4130 Ruscogenin Ruscogenin is an important steroid saponin extracted from Ophiopogon japonicum. It alleviates blood-brain barrier dysfunction induced by cerebral ischemia by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, and has significant anti-inflammatory and antithrombotic activities.



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