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NLR NOD-like Receptor

Cat.No.  Name Information
M54577 Antcin A Antcin A is an NLRP3 inhibitor that inhibits the assembly and activation of NLRP3 inflammatory vesicles. In addition, Antcin A inhibits pyroptosis of Kupffer cells and has hepatoprotective activity.Antcin A can be used in inflammation-related studies.
M54574 Emlenoflast Emlenoflast is a sulfonylurea compound that is also a potent and selective inhibitor of NLRP3 inflammatory vesicles with an IC50 value of less than 100 nM.Emlenoflast can be used in studies related to inflammatory diseases.
M54572 NLRP3-IN-11 NLRP3-IN-11 is a NLRP3 protein inhibitor that is biologically active with an IC50 value of <0.3 μM.NLRP3-IN-11 can be used in studies related to inflammatory and degenerative diseases.
M54571 NLRP3-IN-10 NLRP3-IN-10 is a potent NLRP3 inhibitor with an IC50 of 251.1 nM for inhibition of IL-1β. NLRP3-IN-10 attenuates the formation of ASC speckles and inhibits the activation of NLRP3 inflammatory vesicles.
M45373 NLRP3/AIM2-IN-2 NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome-dependent cellular pyroptosis, with an IC50 value of 0.2392 ± 0.0233 μM.
M45372 NLRP3/AIM2-IN-3 NLRP3/AIM2-IN-3 is a potent inhibitor that interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC and inhibits ASC oligomerization, and has different species-specific effects on NLRP3 and AIM2 inflammasome-dependent pyroptosis. In addition, NLRP3/AIM2-IN-3 inhibited LPS/nigericin-stimulated cell pyroptosis in THP-1 macrophages with an IC50 of 0.077 ± 0.008 μM.
M20827 BMS-986299 BMS-986299 is a first-in-class (first-in-class) NLRP3 inflammatory vesicle agonist that induces IL8 release to activate natural killer (NK) cells with an EC50 of 1.28 μM.
M14102 Cardamonin Cardamonin (Cardamomin) acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
M13338 Trimethylamine N-oxide Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
M10838 JC124 JC124 IS A SPECIFIC INHIBITOR OF THE NLRP3 INFLAMMASOME. JC124 HAS ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS.
M10687 YQ128 YQ128 is a potent, selective second-generation NLRP3 inflammatory body inhibitor,IC50 0.30 μM. YQ128 significantly and selectively inhibits the production of IL-1β, but does not inhibit the production of TNF-α. YQ128 can cross the blood-brain barrier to reach the central nervous system. YQ128 has anti-inflammatory activity.
M10685 Arglabin Arglabin ((+)-Arglabin, a natural product isolated from Artemisia annua, is an inhibitor of the NLRP3 inflammasome. Arglabin has anti-inflammatory and anti-tumor activity. Arglabin's antitumor activity is achieved by inhibiting farnesyl metastase and activating the RAS proto-oncogene.
M10629 Troxerutin Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.
M10583 RRX-001 Rrx-001 is a hypoxic selective epigenetic factor that has been used as a radiation or chemotherapy sensitizer to induce apoptosis. Rrx-001 is an immune checkpoint inhibitor that down-regulates CD47 and SIRP-α. Rrx-001 is also an effective inhibitor of G6PD with strong antimalarial activity. Rrx-001 inhibits the expression of CD47 in tumor cells by inhibiting c-myC, a positive regulator of CD47.
M10136 GSK717 GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor.
M9516 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor able to decrease interleukin-1β release from macrophages. *The compound is unstable in solutions, freshly prepared is recommended
M9082 ISO-1 ISO-1, also known as MIF Antagonist, is a MIF inhibitor with an IC50 of 7 uM. ISO-1 exerts anti-cancer effects on PANC-1 cell proliferation, migration and invasion in vitro, and inhibited PANC-1 cell-induced tumour growth in xenograft mice in vivo.
M7547 NOD-IN-1 NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
M5301 (E)-Cardamonin (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
M4710 Shionone Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure.




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