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ISO-1

Cat. No. M9082
ISO-1 Structure
Synonym:

MIF Antagonist; Macrophage Migration Inhibitory Factor

Size Price Availability
10mg USD 175 4-7 Days
50mg USD 735 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina. ISO-1 significantly inhibits the cytokine activity in vitro. In vivo, administration of ISO-1 resulted in a significant reduction in implant size and vascularity (as assessed by Flk1 mRNA expression) which was not associated with an alteration in the reproductive cycle in mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 235.24
Formula C12H13NO4
CAS Number 478336-92-4
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease.
Nothnick WB, et al. J Endometr. 2011 Sep 30;3(3):135-142. PMID: 24790725.

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.
Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4. PMID: 16115897.

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Keywords: ISO-1, MIF Antagonist; Macrophage Migration Inhibitory Factor supplier, inhibitors

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