|M8994||AM095 free acid||AM095 free acid is a potent LPA1 receptor antagonist which inhibited GTPγS binding to CHO cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively.|
|M8993||BMS-986020||BMS-986020 (also known as AM152) is a potent and selective LPA1 antagonist.|
|M8992||AM966||AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model.|
|M7674||AM095 sodium||AM095 is a potent and selective, orally bioavailable antagonist of lysophosphatidic acid receptor1 (LPA1).|
|M6125||AKP-11||AKP-11 has potent immune modulatory activity for treatment of EAE/MS, but with relatively low adverse effects suggesting AKP-11 as a potential therapeutic drug for MS patients.|
|M2787||JTE 013||JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.|
|M2428||BAF312||BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.|
|M2213||Ki16425||Ki16425 is a LPA receptor antagonist with Ki values of 0.34, 6.5 and 0.93 μM for the human LPA1, LPA2 and LPA3 receptors, respectively.|
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