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BMS-986020

Cat. No. M8993
BMS-986020 Structure
Synonym:

AM152

Size Price Availability Quantity
5mg USD 220 In stock
10mg USD 350 In stock
25mg USD 650 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BMS-986020 selectively inhibits the LPA receptor, which is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions like cell proliferation, platelet aggregation, smooth muscle contraction, chemotaxis, and tumor cell invasion, among others.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 482.53
Formula C29H26N2O5
CAS Number 1257213-50-5
Purity >98%
Solubility DMSO: ≥ 50 mg/mL
Storage at -20°C
References

Lysophospholipid receptors in drug discovery.
Kihara Y, et al. Exp Cell Res. 2015 May 1;333(2):171-7. PMID: 25499971.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-986020, AM152 supplier, LPL Receptor, inhibitors

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