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BMS-986020

Cat. No. M8993
BMS-986020 Structure
Synonym:

AM152

Size Price Availability Quantity
5mg USD 95  USD95 In stock
10mg USD 150  USD150 In stock
50mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

BMS-986020 selectively inhibits the LPA receptor, which is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions like cell proliferation, platelet aggregation, smooth muscle contraction, chemotaxis, and tumor cell invasion, among others.

Chemical Information
Molecular Weight 482.53
Formula C29H26N2O5
CAS Number 1257213-50-5
Solubility (25°C) DMSO: ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kihara Y, et al. Exp Cell Res. Lysophospholipid receptors in drug discovery.

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  Catalog
Abmole Inhibitor Catalog




Keywords: BMS-986020, AM152 supplier, LPL Receptor, inhibitors, activators


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