|M13686||MKC8866||MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro.|
|M13685||GSK2850163||GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.|
|M13384||Kira8||Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM.|
|M10395||MKC-3946||MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.|
|M9621||KIRA6||KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM.|
|M8331||STF-083010||STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response.|
|M5283||4μ8C||4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.|
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