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IRE1 IRE1

Cat.No.  Name Information
M8331 STF-083010 STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response.
M27898 IXA4  IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response). IXA4 reduces secretion of APP through IRE1 activation.
M13686 MKC8866 MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro.
M13384 Kira8 Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM.
M10395 MKC-3946 MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.
M9621 KIRA6 KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM.
M5283 4μ8C 4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
M41517 Z4P Z4P is a BBB-permeable IRE1 inhibitor (IC50: 1.11 μM).
M41516 IRE1α kinase-IN-9 IRE1α kinase-IN-9 is a potent IRE-1α inhibitor, exhibits an average IC50 value of <0.1 μM.
M41515 IRE1α kinase-IN-8 IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor.
M29438 Kira8 Hydrochloride Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
M29035 KIRA-7  KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.
M28661 B I09  B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
M13685 GSK2850163 GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.




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