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IRE1 IRE1

Inhibitors

Cat.No.  Name Information
M13686 MKC8866 MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro.
M13685 GSK2850163 GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.
M13384 Kira8 Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM.
M10395 MKC-3946 MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.
M9621 KIRA6 KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM.
M8331 STF-083010 STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response.
M5283 4μ8C 4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.



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