Inhibitors
Cat.No. | Name | Information |
---|---|---|
M13686 | MKC8866 | MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. |
M13685 | GSK2850163 | GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. |
M13384 | Kira8 | Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM. |
M10395 | MKC-3946 | MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
M9621 | KIRA6 | KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM. |
M8331 | STF-083010 | STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. |
M5283 | 4μ8C | 4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
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