IRE1 IRE1

Inhibitors

Cat.No.	Name	Information
M13686	MKC8866	MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC₅₀ of 0.29 μM in human vitro.
M13685	GSK2850163	GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.
M13384	Kira8	Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM.
M10395	MKC-3946	MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.
M9621	KIRA6	KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM.
M8331	STF-083010	STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response.
M5283	4μ8C	4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.